Oligohydramnios - Causes - Treatment - Prognosis - TeachMeObGyn (2024)

Oligohydramnionrefers to a low level of amniotic fluid during pregnancy.

It is defined by an amniotic fluid index that is below the 5th centile for the gestational age, and is thought to affect approximately 4.5% of term pregnancies [AJOC, 2004].

In this article, we shall look at the aetiology, investigations and management of oligohydramnios.

Pathophysiology

The volumeof amniotic fluid increases steadily until 33 weeks of gestation. It plateaus from 33-38 weeks, and then declines – with the volume of amniotic fluid at term approximately 500ml.

Itis predominantly comprisedof the fetal urine output, with small contributions from the placenta and some fetal secretions(e.g. respiratory).

The fetus breathes and swallows the amniotic fluid. It gets processed, fills the bladder and is voided, and the cycle repeats.Problems with any of the structures in this pathway can lead to either too much or too little fluid.

Anything that reduces the production of urine, blocks output from the fetus, or a rupture of the membranes (allowing amniotic fluid to leak) can lead to oligohydramnios.

Aetiology

The main causes of oligohydramnios are:

• Preterm prelabour rupture of membranes
• Placental insufficiency – resulting in the blood flow being redistributed to the fetal brain rather than the abdomen and kidneys. This causespoor urine output.
• Renal agenesis (known as Potter’s syndrome)
• Non-functioning fetal kidneys, e.g. bilateral multicystic dysplastic kidneys
• Obstructive uropathy
• Genetic/chromosomal anomalies
• Viral infections (although may also cause polyhydramnios)

Clinical Assessment

Oligohydramnios is a diagnosis made via ultrasound examination. Therefore, the clinical assessment of the patient is directed at establishing anyunderlying cause:

• History
  • Inquire about symptoms of leaking fluid and feeling damp all the time (often described as new urinary incontinence).
• Examination
  • Measure the symphysis fundal height.
  • Perform a speculum examination (can a ‘pool’ of liquor be seen in the vagina?).
• Ultrasound
  • Assess for liquor volume, structural abnormalities, renal agenesis and obstructive uropathy.
  • Measure fetal size. Small babies can result from placental insufficiency, which also causes oligohydramnios.There may also be a rise in pulsatility index of the umbilical artery Doppler in placental insufficiency.
• Karyotyping (if appropriate) – particularly in cases ofearly and unexplained oligohydramnios.

When considering ruptured membranes as a cause for oligohydramnios, a bedside test can be performed to detect the presence of IGFBP-1 (insulin-like growth factor binding protein-1) or PAMG-1 (placental alpha-microglobulin-1) in the vagina. These proteins are found in amniotic fluid, and if detected, strongly suggest membrane rupture.

Management

The management of oligohydramnios is largely dependent on the underlying cause. The two most common causes are rupture of the membranes and placental insufficiency.

Ruptured Membranes

If oligohydramnios is due to ruptured membranes, labour is likely to commence within 24-48 hours in most pregnancies.

In cases ofpreterm rupture of membranes(i.e. before 37 weeks’ gestation), and where labour doesn’t start automatically, induction of labour should be considered around 34-36 weeks(in the absence of infection).

A course of steroids should be given to aid fetal lung development, and antibiotics to reduce the risk of ascending infection.

Placental Insufficiency

In women where oligohydramnios is caused byplacental insufficiency, the timing of delivery depends on a number of factors:

• Rate of fetal growth
• Umbilical artery and middle cerebral artery Doppler scans
• Cardiotocography

These babies are likely to be delivered before 36-37 weeks.

Prognosis

Oligohydramnios in the second trimestercarries a poor prognosis. In the majority of these cases, there is premature rupture of membranes (which may or may not be associated with infection), with subsequent premature delivery and pulmonary hypoplasia – which can cause significant respiratory distress at birth

When oligohydramnios is associated with placental insufficiency, there is also a higher rate ofpreterm deliveries (usually through planned induction of labour). These cases will carry a poorer prognosis than that of a normally grown fetus.

Amniotic fluid also allows the fetus move its limbs in utero (exercise). Without this, the fetus candevelop severe muscle contractures –which maylead to disability despite physiotherapy after birth.